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Effect of NF-κB Inhibitor PDTC on a Herpetic Stromal Keratitis Mouse Model

   
@article{YKXB3672,
	author = {Yiqun Geng 和 Yunliang Shao 和 Yu Zhang 和 Zeyi Li},
	title = {Effect of NF-κB Inhibitor PDTC on a Herpetic Stromal Keratitis Mouse Model},
	journal = {眼科学报},
	volume = {27},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Purpose:To investigate the effect of NF-κB inhibitor PDTC on inflammation response in mice with herpetic stromal keratitis (HSK). Methods:A total of 120 female BALB/c mice,aged 4 -6 weeks, were treated by scuffing the epithelium of the right cornea with the tip of a 30G syringe needle, and approximately 1×106 PFU of HSV-1virus was seeded onto the corneal surface. The eye was then exposed to 170 mJ/cm2 of UV light 7 weeks later, in order to induce the relapse of HSK. PDTC eye drops were adjusted to various concentrations (0.1,1.0, and 10 mg/ml) with PBS; PBS only was used on control animals.All animals received PDTC or PBS eye drops 6 times/day,1 drop/time, for 7 consecutive days. Mice were sacrificed at 8h, and 1, 3, and 7d after administration. Corneal tissues were prepared for the detection of IL-1β, IL-4, IL-6, and IL-12 by ELISA and histological study. Results: Neutrophilic leukocytes and lymphocytes were found in the corneas of HSK mice. ELISA results showed fluctuating expressions of IL-1β, IL-4, IL-6, and IL-12. The IL-1β and IL-4 expressions were significantly lower in the high dose group than in the control group (P},
	url = {https://ykxb.amegroups.com/article/view/3672}
}