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Intravitreous High Expression Level of Netrin-1 in Patients with Proliferative Diabetic Retinopathy

   
@article{YKXB3713,
	author = {Jiaolian Liu 和 Xiaobo Xia 和 Siqi Xiong 和 Yunzheng Le 和 Huizhuo Xu},
	title = {Intravitreous High Expression Level of Netrin-1 in Patients with Proliferative Diabetic Retinopathy},
	journal = {眼科学报},
	volume = {26},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Purpose:To investigate the significance of netrin-1 and vascular endothelial growth factor(VEGF) in the pathogenesis of retinal angiogenesis,the levels of netrin-1 and VEGF in the vitreous fluid and serum of the proliferative diabetic retinopathy (PDR) and non-proliferative diabetic retinopathy (non-PDR) patients were measured. We then determined the netrin-1 and VEGF expression in the oxygen induced retinopathy (OIR) mice retina. Methods:A total of 18 eyes from 18 patients were included in our study and 10 of them were collected from PDR patients and 8 from non-PDR patients. Undiluted vitreous fluid samples were collected during pars plana vitrectomy. Appropriate blood samples were collected if possible. Netrin-1 and VEGF levels in the vitreous fluid and plasma were determined by Enzyme-linked Immunosorbent Assays.OIR mice models were established,and netrin-1 and VEGF levels were determined by immunohistochemistry analysis. Results:The levels of netrin-1 and VEGF in the vitreous of PDR patients were significantly higher than those in the controls (Mediannetrin-1=509.94 vs.85.91 pg/ml,P},
	url = {https://ykxb.amegroups.com/article/view/3713}
}