@article{YKXB3808,
author = {Wei Liu 和 Xiangyin Sha 和 Ye Wen 和 Wenting Zhao 和 Wei Luo 和 Zanmei Hua},
title = {Effect of Avastin on the migration and invasion of pterygium fibroblasts},
journal = {眼科学报},
volume = {29},
number = {4},
year = {2016},
keywords = {},
abstract = {Purpose:.To evaluate the effect of Avastin on human pterygium fibroblast migration and invasiveness.Methods:.VEGF secretion was compared between human pterygium fibroblasts and conjunctival fibroblasts by measuring VEGF-A by ELISA. The influence of Avastin on HPF migration and invasiveness was observed by wound scratch and Transwell migration assays..The expression of p-ERK1 / 2 and p-FAK was analyzed by western blotting.Results:(1)VEGF was secreted in higher amounts by human pterygium fibroblasts than by conjunctival fibroblasts.(2)Avastin treatment decreased HPF migration and invasion.(3)Avastin significantly decreased the expression of p-ERK1 / 2and p-FAK in human pterygium fibroblasts.Conclusion:.Avastin can inhibit migration and invasion of HPFs by decreasing the expression of p-ERK1 / 2 and p-FAK.},
url = {https://ykxb.amegroups.com/article/view/3808}
}