Clinical Application of Photopic Negative Response of the Flash Electroretinogram in Primary Open-angle Glaucoma
摘要
Purpose:.To evaluate the diagnostic performance of the photopic negative response (PhNR) for the detection of primary open-angle glaucoma (POAG). Methods:.Fifty-two normal subjects (52 eyes) and 173 POAG patients.(173 eyes) were studied. The PhNR was elicited using a white stimuli on a white background..The mean deviation (MD) and pattern standard deviation (PSD) of the visual field were measured using standard automated perimetry (SAP)..Spectral domain optical coherence tomography (SD-OCT).was used to measure the mean thickness of the retinal nerve fiber layer (RNFL). Results:.In the glaucoma group,.as compared to the normal group,.the amplitudes of a-waves,.b-waves and PhNR were significantly smaller (P<0.001), and the PhNR implicit time was significantly longer.(P=0.004). The MD, PSD and mean thickness of the RNFL were significantly correlated with the amplitude of the PhNR (P<0.001). The area under the receiver operating characteristic curve (AUCs) for the amplitudes of a-waves,.b-waves and PhNR were 0.853,.0.830 and 0.918, respectively. When the specificity was ≥95%, the sensitivities were 60.4%, 54.2% and 85.4% respectively. Conclusion:The PhNR amplitude was reduced even when the loss in visual field sensitivity was mild, which suggests that PhNR might be a useful indicator of early glaucoma disease.
