Inter-ethnic variation of ocular traits——design and methodology of comparison study among American Caucasians,American Chinese and mainland Chinese
摘要
Purpose:To summarize the design and methodology of a multi-center study.With the existed ethnic differences of glaucoma,this survey will explore the differences with regard to anterior and posterior ocular segment parameters between Caucasians and Chinese.Methods:In this study,four cohorts including American Caucasians and American Chinese from San Francisco,southern mainland Chinese from Guangzhou,and northern mainland Chinese from Beijing were prospectively enrolled for a series of eye examinations and tests from May 2008 to December 2010.A total of 120 subjects including 15 of each gender in each age decade from 40s to 70s were recruited for each group.Data of the following tests were collected:a questionnaire eliciting systemic and ocular disease history,blood pressure,presenting and best corrected visual acuity,auto-refraction,Goldmann applanation tonometry,go nioscopy,A-scan,anterior segment optical coherence tomography (ASOCT),ultrasound biomicroscopy (UBM),visual field (VF),Heidel berg retinal tomography (HRT),OCT for optic nerve,and digital fundus photography.Conclusion:this study will provide insights to the etiologies of glaucoma especially PACG through inter-ethnic comparisons of relevant ocular anatomic and functional parameters.
