Lens Coloboma and Associated Ocular Malformations

Purpose:Lens coloboma is a rare congenital disorder of crystalline lens characterized by notching of the equator of the lens.Coloboma can occur in isolation or with other ocular malformations. The authors reported 5 cases of lens coloboma associated with some ocular malformations. Methods:Case reports.The clinical features,imaging findings and associated ocular malformations were reported. Results:One case was not associated with ocular anomalies. One patient was involved with iris and choroid coloboma;another subject suffered from total cataract;and the fourth patient was affected by lens dislocation.The remaining case included aniridia. The pathogenic mechanisms and relationship of the ocular malformations have been discussed. Conclusion:Lens coloboma can be associated with other ocular malformations, such as iris coloboma, choroid colobma, localized or total caratact.